Endocrine Abstracts

Thyroid storm is a rare complication of thyrotoxicosis, life-threatening if not managed appropriately.We report a 43-year-old woman who presented to emergency services with shortness of breath, palpitations and weight loss. She was pale, cachectic, in atrial fibrillation and had signs of decompensated heart failure. Investigations showed: WBCs: 3.2×109/l, neutrophils 2.1×109/l, Hb 53 g/l, platelet 233, TSH <0.02 mIU/l, FT4 64 (10–25 pm...

Introduction: Graves’ thyrotoxicosis has been known to affect other organ systems in the body including the liver. However, severe hepatitis in this clinical context is quite rare.Case report: We report a 55-year-old man who presented with marked weight loss and jaundice. In addition, he had a diffuse goitre with fine tremors in the hands. Laboratory work-up revealed thyrotoxicosis with FT4 of 87.9 pmol/l and TSH of <0.01 mIU/l. He ha...

Pheochromocytoma is a rare catecholamine-secreting tumor. It is potentially curable but can cause life-threatening hypertension or cardiac arrhythmias. We report a 58- years- old woman with no significant past medical history who was admitted through the emergency department with complaints of chest pain, palpitation, and nausea. She reported six months history of episodic palpitation and throbbing headaches, sometimes associated with light-headedness and dizziness. Hence, she...

We present a case of a 26 years old female who was rushed to hospital with 4 days history of abdominal pain, vomiting and dizziness. She also had one episode of diarrhoea. Further history revealed that she had lost 32 kilograms of weight over the last 18 months through diet and exercise. There were no signs suggestive of an eating disorder.On examination she was peripherally cold, tachycardic (117/min), hypotensive (86/50 mmHg) and sweaty. Her Glasgow Co...

Context: Recent studies showed association between hyperaldosteronism and low bone density among patients with primary aldosteronism (PA) due to secondary hyperparathyroidism.Objective: To assess bone turnover markers and bone mineral density (BMD) of PA patients compared to essential hypertension.Design: This was an open label, prospective, case-controlled study, conducted over 12 months.Setting: Eighteen co...

Introduction: A significant number of patients are intolerant of anti-thyroid drugs (ATD) and thyroidectomy remains the only treatment option available to patients who decline radioiodine as definitive therapy. As patients with poorly controlled thyrotoxicosis are at risk of developing thyroid storm, optimal pre-operative control of hyperthyroidism is essential. Rapid thyroid blockade (RTB) with the contrast agents sodium ipodate and iopanoic acid were attractive treatment opt...

There is concern about the effects of long-term bisphosphonate use. A ‘treatment holiday’ is now considered after 5 years but there is no evidence as to the best way in which to monitor this.Aim: To look at the effect that a ‘treatment holiday’ has on the bone turnover marker, amino-terminal propeptide (P1NP) and bone mineral density (BMD).Methods: A retrospective case note review of 55 patients currently underg...

IntroductionGlucagon-like peptide-1 (GLP-1) plays an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). However, results from previous studies on the GLP-1 secretory responses in individuals with different glucose tolerance states remain controversial. This may be contributed by the heterogeneous characteristics of the patients recruited.AimTo examine whether GLP-1 secretion is affected...

IntroductionGlucagon-like peptide-1 (GLP-1) plays an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). Results from some studies on post-OGTT GLP-1 responses involving East Asians with abnormal glucose tolerance states tend to differ from the West. This may be attributed to the different diabetic phenotypes found in East Asians.AimTo examine post-OGTT GLP-1 responses in subjects with n...

Introduction: Acute myocardial infarction (AMI) is a stressful condition in which it stimulates the hypothalamus-pituitary-adrenal axis leading to mark increase in the production of cortisol. Adrenal insufficiency (AI) has been shown to be associated with morbidity and mortality in acute coronary syndrome patients. To date, none study has been performed to determine prevalence of AI among patient with AMI.Objectives: The aim of this study is to determine...